Mitochondrial dysfunction in ASD

Recently, evidence has accumulated that some children with autism spectrum disorders (ASDs) have mitochondrial disease (also known as mitochondrial disorders) or mitochondrial dysfunction. Mitochondrial dysfunction generally refers to mitochondria that are impaired in function but not severely impaired enough to fulfill the criteria necessary for the diagnosis of mitochondrial disease. In essence, mitochondrial disease can be thought of as a severe form of mitochondrial dysfunction, and mitochondrial dysfunction can be thought of as a less severe form of mitochondrial disease. If mitochondrial dysfunction can be represented by an engine that is sputtering, mitochondrial disease would be represented by an engine that is constantly in the repair shop.

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