Recent Posts by Aaron Grable

Treatment of Methylation Deficits in Autism Spectrum Disorder

Once a rare childhood disorder with an incidence of 1 in 10,000 twenty years ago, autism now affects 1 out of every 150 children. Classified as a neurodevelopmental disorder and diagnosed by psychological testing, autism spectrum disorder (ASD) is often perceived to be a genetically-based mental disorder. However, current research has shown it to be…
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Risk of Anesthesia Regression

Children with autism spectrum disorder (ASD) have a range of medical problems involving many organ systems. A subset of children with ASD hasve abnormal mitochondrial energy production and function that contributes to their physical, cognitive, and behavioral impairments. The presence of mitochondrial dysfunction increases the risk for potential damage to the brain, which is dependent…
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Mitochondrial dysfunction in ASD

Recently, evidence has accumulated that some children with autism spectrum disorders (ASDs) have mitochondrial disease (also known as mitochondrial disorders) or mitochondrial dysfunction. Mitochondrial dysfunction generally refers to mitochondria that are impaired in function but not severely impaired enough to fulfill the criteria necessary for the diagnosis of mitochondrial disease. In essence, mitochondrial disease can be…
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Review of Treatments for Seizures in ASD

Despite the fact that seizures are commonly associated with autism spectrum disorder (ASD), the effectiveness of treatments for seizures has not been well studied in individuals with ASD. This manuscript reviews both traditional and novel treatments for seizures associated with ASD. Studies were selected by systematically searching major electronic databases and by a panel of…
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